Anti-aging properties of metformin

Introduction: Life expectancy of human population is being constantly prolonged, hence there a lot research into drug that will prevent the effects aging. There are many reports metformin, which used in type 2 diabetes, has anti-aging effects. It belongs to group biguanides and been since 1950s. relatively safe, cheap effective drug, makes it promising subject for studies. The purpose this review present latest developments field. Material methods: PubMed scientific base was searched using following keywords: aging, anti-aging, years 2017-2021. Results: Numerous studies show metformin an impact on aging through nutrient pathway, AMPK signaling its reactive oxygen species. In addition, anti-cancer effect, inhibiting, among others, rectal cancer cells p53 mutant colon cancer. Research rodents shown organs, including CNS, ovaries, prostate, heart muscle skin. Conclusions: Metformin, most commonly oral other mechanisms action. Its effect works organs our bodies, gives hope find substance. However, multicentre, randomized trials needed determine exact dose, possible side effects, various organisms.